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Job overview
Come and join our team and help us improve Genetic Services for Rare Disease
Band 7 Translational Bioinformatician required
Do you want to help shape the future of the NHS Rare Disease Genomics Service?
We are looking for a skilled and enthusiastic postdoctoral Bioinformatician to join our team within the North Thames Genomic Medicine Service at Great Ormond Street Hospital.
Our team is transforming patient care by developing pipelines for rapid, comprehensive diagnosis of monogenic conditions using whole genome sequencing. We are also expanding the use of long‑read sequencing technologies and integrating AI to improve efficiency and diagnostic yield. We are exploring expanding our non-invasive prenatal diagnosis service based on analysis of cell free DNA to include screening for selected monogenic conditions.
Main duties of the job
In this exciting role, you will develop analytical pipelines, optimise and maintain existing workflows, and contribute to database development projects. You will play a key role in evaluating new bioinformatics applications, supporting infrastructure planning, and collaborating closely with scientific teams across the service.
If you are committed to contributing to a well‑established translational research group with an international reputation for driving innovation into clinical practice, this post will be an excellent fit for you. This Band 7 position is available immediately, funded until 31st March 2028. You will join an enthusiastic, friendly, and motivated multidisciplinary group, working across both the Clinical Bioinformatics and Translational Research teams.
This role is ideal for postdoctoral clinical Bioinformaticians seeking to broaden their research experience and contribute to translating new innovations into routine patient care. We are particularly looking for someone with expertise in AI that could be applied to genomic variant filtering but expertise in other areas such as analysis of cfDNA would also be welcomed.
Detailed job description and main responsibilities
The full job description provides an overview of the key tasks and responsibilities of the role, and the person specification outlines the qualifications, skills, experience, and knowledge required. For both documents please view the attachment.
Person specification
Skills/Abilities
Essential
- Evidence of excellent inter-personal communication skills
- Excellent organisational and time management skills with ability to prioritise tasks effectively
- Ability to develop and maintain excellent communication and working relationships
- Advanced problem-solving skills
- Able to provide specialist advice to laboratory staff
- Able to present data at departmental and inter-departmental meetings
- Awareness of clinical significance of genetics findings and implications for patients
- Work to deadlines, operating autonomously and as part of a team
- Knowledge and understanding of ISO15189 accreditation standards and their application to a genomics laboratory
- Ability to write and follow bioinformatics protocols
- Ability to work on site in line with lab policy on remote working, which is currently a minimum of 20%.
Experience/Knowledge
Essential
- Knowledge of confidentiality and data protection processes and procedures
- Experience of developing, implementing and maintaining bioinformatic data analysis pipelines
- Experience with creating, querying and maintaining databases, particularly MySQL or PostgreSQL
- Advanced use of git version control
- Knowledge of bash and shell scripting
- Ability to work in a Unix/Linux environment
- Up to date knowledge of the relevant scientific literature
- Evidence of professional and personal development.
- Experience in deploying production ready applications to support genetic services
- Experience of project management
- Demonstrable experience in a clinical diagnostic department
- Detailed knowledge of core computer service concepts
Desirable
- Experience using docker for development
- Experience in scientific workflow languages for genomic pipelines (e.g. Nextflow)
- Advanced knowledge of the Python programming language, and commonly used Python libraries and web frameworks (e.g. Django and Flask)
- Experience testing python code e.g. using pytest
GOSH Culture and Values
Essential
- Our Always values
- 1) Knowledge and understanding of diverse backgrounds and perspectives. 2) Understanding of Diversity and Inclusion challenges in the workplace. 3) Demonstrable contribution to advancing Equality, Diversity and Inclusion in the Workplace
Academic/Professional qualification/Training
Essential
- MSc in Bioinformatics/Computational Biology or equivalent Postgraduate qualification
- State Registered Clinical Bioinformatician (HCPC)
Desirable
- Higher degree (PhD) in Bioinformatics or a related field
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Applying for this NHS job
This advert is for Translational Bioinformatician with Great Ormond Street Hospital for Children NHS Foundation Trust in London, London, England. It is listed as a Band 7 Health science services role. The advertised salary is £58,133 - £65,261 Inclusive per annum pro rata. The contract type is 2 years (Fixed Term until 31st March 2028). The application deadline is 12 Jul 2026.
Before you apply, compare the job description with the person specification and mirror the employer's essential criteria in your supporting information. Use the vacancy title, employer, location, salary, contract type, closing date and posted date (26 Jun 2026) to decide whether this role fits your current NHS job search. If the employer can close applications early, prepare the application before the stated deadline rather than waiting for the final day.
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