Senior Genomics Technician

Job overview

We are seeking to appoint a highly motivated Senior Genomics Technician to join the Genomics Research Platform and Single Cell Laboratory within the R&D Department at Guy’s and St Thomas’ NHS Foundation Trust.

Our laboratory employs state-of-the-art genomics technologies to accelerate the translation of research into clinical applications. This is an exciting opportunity for an individual with a strong interest in genomics to contribute to cutting-edge research projects.

The successful candidate will play a key role in supporting our genomics service provision, enabling both academic and clinical research projects. Experience is next-generation sequencing (NGS) is essential, and experience with single-cell or spatial transcriptomics technologies is highly desirable. In this role, you will contribute to advancing innovative research with the ultimate aim of improving patient outcomes.

Main duties of the job

As a Senior Genomics Technician, you will undertake scientific projects using a wide range of genomics workflows, driving experiments in bulk-cell sequencing, single-cell analysis, and spatial transcriptomics, providing critical insights for our research objectives. You will play a pivotal role in the optimisation and validation of R&D workflows, evaluating and integrating emerging, cutting-edge technologies into our core pipeline. Working within a collaborative team, you will provide essential technical support and mentorship, ensuring that high-quality data and project outputs are delivered with precision and efficiency.

You will hold at least a BSc (or equivalent) in Biology/Life Sciences or relevant discipline plus experience gained through working in a research/service lab. Knowledge, skills and experience in genomics techniques is essential.

Key responsibilities:

• Workflow execution: Perform end-to-end genomics experiments, from sample preparation to library construction to sequencing, using state-of-the-art platforms.
• Innovation and R&D: Contribute to the development and refinement of lab protocols to enhance sensitivity, throughput and data quality.
• Technical expertise: As the technical expert in genomics workflows, provide training and guidance to junior team members, service users and collaborators.
• Operational Excellence: Maintain rigorous quality control standards and manage project timelines to ensure seamless delivery of results.

Detailed job description and main responsibilities

The Genomics Research Platform, a prestigious collaboration between Guy’s & St Thomas’ NHS Foundation Trust (GSTT) and King’s College London (KCL), is seeking a highly motivated Senior Genomics Technician. This permanent position offers an exciting opportunity to work at the forefront of a rapidly evolving field, contributing to both day-to-day service provision and innovative R&D projects.

As a key member of our specialist team, you will utilise a range of advanced molecular biology techniques to process samples using the latest genomics platforms. This role is ideal for a detail-oriented individual looking to advance their career within a high-impact, multidisciplinary environment that bridges clinical excellence and world-class research.

Main Duties and Responsibilities

• Service Provision: Deliver high-quality genomics services to platform users, including single-cell transcriptomics profiling, spatial transcriptomics, and bulk DNA/RNA sequencing.
• Operational Excellence: Maintain meticulous records of all laboratory work and service operations for assigned projects, ensuring full traceability and data integrity.
• Collaboration & Communication: Work synergistically with team members and key stakeholders across GSTT and KCL to ensure a streamlined and efficient service.
• Research & Development: Actively contribute to the development and refinement of new Standard Operating Procedures (SOPs) and experimental protocols.
• Scientific Engagement: Participate in group meetings, contribute to data discussions, and present experimental findings to the wider team.

Qualifications and Experience

• BSc/MSc/PhD in Biomedical Science or an equivalent discipline with a proven track record in molecular biology workflows.
• Minimum of 3 years of experience in genomics/molecular biology, specifically within a research or service laboratory environment.
• Hands-on experience in manual or automated library preparation for Next-Generation Sequencing (NGS).
• Ability to strictly follow SOPs and worksheets with exceptional attention to detail to ensure reproducible results.
• Proven ability to work independently and complete complex projects within defined timelines and budgetary constraints.
• A fast learner who is receptive to specialised training and comfortable working under close supervision during the initial training period.