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Job overview
We are looking to appoint a Band 4 laboratory technician to the Wincup Lab, to support the FOREUM funded research project ‘Predicting Risk of Evolution to Lupus through Understanding Dysfunctional Immune Tolerance in Exhausted Tregs (PRELUDE)’. The Wincup lab is a translational immunology group led by Dr Chris Wincup (Consultant Rheumatologist at King’s College Hospital / Adjunct Senior Lecturer at King’s College London).
The group focuses on the immunopathology of systemic lupus erythematosus (SLE) and related autoimmune diseases and is comprised of Rheumatology Researchers including clinicians and post-doctoral research associates, and as part of the Centre for Rheumatic Disease Clinical Trials Group, work closely with Clinical Research Nurses, Clinical Research Practitioners, and trial coordinators for project delivery. Our Centre was recently recognised as a EULAR Centre of Excellence for the quality of research conducted. The Rheumatology Research Team also have a close working relationship with the NIHR King’s Clinical Research Facility with access to staff cover and facilities, and partnerships with Haematology and Renal research teams.
Main duties of the job
The post holder will support the management and maintenance of samples processed within the Wincup lab alongside the lab group post-doctoral research associates. You will also be responsible for contributing to robust Standard Operating Procedures related to this area of practice. The post-holder will require proficiency in core immunology techniques including peripheral blood mononuclear cell (PBMC) isolation, cell culture, and multiparameter flow cytometry. The post-holder will be responsible for processing samples from a longitudinal patient cohort, performing functional Treg assays, and contributing to the maintenance of a well-organised biobank.
Detailed job description and main responsibilities
Process peripheral blood samples from SLE patients and at-risk individuals enrolled in the PRELUDE study, including PBMC isolation, cryopreservation, and biobanking
Maintain and organise the PRELUDE study biobank, ensuring accurate sample tracking and storage logs
Perform multiparameter flow cytometry to characterise regulatory T cell (Treg) phenotype and function, including panel preparation, sample acquisition, and data export
Contribute to flow cytometry data analysis using FlowJo or equivalent software
Conduct functional Treg suppression assays and other cell-based immunological assays as directed by the postdoctoral team
Carry out molecular biology techniques including RNA extraction, cDNA synthesis, and gene expression analysis where required
Maintain accurate and detailed laboratory records in line with GCP and institutional requirements
To be able to follow departmental SOPs and prepare samples accurately
To be able to use computer systems correctly, enter data accurately from transcription sheets or request forms
To assist in the training and supervision of staff / students working in the Wincup Group as part of their induction.
Ensure all research activity is conducted in accordance with relevant NHS and university research governance frameworks
Attend and contribute to regular laboratory meetings and journal clubs
Assist with ordering laboratory consumables and maintaining equipment logs
Contribute to the preparation of data for presentations, grant reports, and manuscripts as directed
Person specification
Skills and competencies
Essential
- Competency in standard IT and data management tools
- Ability to communicate effectively using clear written and spoken English
- Strong written and verbal communication skills
knowledge and experience
Essential
- Hands-on wet laboratory experience, including cell culture and PBMC isolation
Desirable
- Experience with multiparameter flow cytometry, including panel preparation and sample acquisition
- Experience with molecular biology techniques (RNA extraction, gene expression analysis)
- Familiarity with flow cytometry analysis software (e.g. FlowJo)
- Basic data analysis skills, including experience with R, Python, or equivalent
- Experience working within a clinical or translational research setting
education & qualifications
Essential
- BSc degree in Immunology, Biomedical Science, Cell Biology, or closely related life science discipline
Desirable
- MSc or higher degree in a relevant subject area
- GCP certification (must be obtained prior to or shortly after commencement of post)
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Applying for this NHS job
This advert is for Laboratory Technician with King's College Hospital NHS Foundation Trust in London, London, England. It is listed as a Band 4 Health science services role. The advertised salary is £34,186 - £37,389 per annum inc HCA's. The contract type is 12 months (Fixed term to deliver specific project). The application deadline is 27 Jul 2026.
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