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Job overview
Clinical Research Fellow– UCL/UCLH Institute of Neurology, Ataxia Centre Applications are invited for a Clinical Research Fellow in the Ataxia Centre, UCL/UCLH Department of Neuroscience and Neurogenetics, UCL Institute of Neurology, under the supervision of Prof Paola Giunti.
The post offers an exciting opportunity to gain experience of translational research as part of an internationally recognised multi-disciplinary team.
Main duties of the job
The postholder will be an essential member of the research team at the Ataxia Centre, providing clinical and research input into the Centre’s research programme into Ataxia and will work closely with the Principal Investigators (PIs), Clinical Research Fellows and Clinical Trials nurses. Their primary role will be as sub-investigator in clinical drug trial: A phase 1/2a, open-label trial to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple ascending doses of intrathecally administered VO659 in participants with spinocerebellar ataxia types 1, 3. assessing the safety of this novel Antisense oligonucleotide(ASO) treatment in patients with these rare diseases. He/she will also have the opportunity to participate in current basic and observational research including longitudinal studies of dominant and recessive ataxias and at-risk groups and healthy volunteers to identify reliable biomarkers of disease and develop new therapeutic targets.
The postholder will gain extensive experience in the set up and execution of clinical trials and laboratory based / translational research. They will also be involved in the clinical activity of the Ataxia clinics and the multidisciplinary meeting.
Applicants should have a medical degree and eligible for full registration with the GMC at time of appointment and hold a current licence to practise and have previous experience in neurology, or general medicine and excellent skill in performing lumbar puncture
Detailed job description and main responsibilities
For the full Person Specification and more information regarding the main responsibilities of this role, please refer to the attached Job Description.
Please note, due to anticipated high volumes of applications, this vacancy may close earlier than the listed closing date. You are advised not to delay submitting your completed application
The successful candidate will have good inter-personal skills, the ability to work co-operatively in a multidisciplinary setting and the ability to demonstrate a record of academic clinical excellence. Please note that if you have not heard from us within 3 weeks of the closing date of the advert to assume that you have not been shortlisted on this occasion.
Come and be a part of the best NHS trust in England to work for, according to our staff*
* UCLH top trust to work at in England - In the most recent NHS staff survey UCLH had the highest percentage of staff who said they would recommend us as a place to work, out of all general acute or acute/community NHS trusts in England – for the third year in a row.
UCLH recognises the benefits of flexible working for staff – To find out more, visit: Flexible working.
To discover more about what makes UCLH a great place to work, visit: Why Choose UCLH?
Person specification
Values
Essential
- Demonstrate ability to meet Trust Values of safety, kindness, teamwork and improving
Experience
Essential
- Clinical research experience/ understanding of research methodology
- Experience of pediatrics’, neurology and/ or clinical genetics
- Experience in delivering evidence-based practice
- Experience of explaining complex concepts to patients in a clear and simplified manner with a very high level of consideration &care for patients, their careers and families
- Experience of formal/informal teaching of patients and staff
- Experience of acting as a patient advocate
Desirable
- Experience of working in the NHS
- Experience of working with patients (children /adults) with neurodegenerative disorders
Communication
Essential
- Computer literacy
- Proven ability to communicate effectively in writing
- Proven ability to communicate verbally
- Good inter -personal skills with an ability to work co -operatively in a multidisciplinary setting.
Desirable
- Medical and scientific writing skills
- Aptitude for data analysis
Skills and Abilities
Essential
- Previous experience in audit and evaluation
- Ability to work under own initiative
- Able to work autonomously with supervision
- Able to work across organisational and professional boundaries
Desirable
- Experience of formal/informal teaching of patients and staff
- Experience of acting as a patient advocate
Knowledge and Qualifications
Essential
- Educated to degree level (Medical Degree)
- Eligible for full registration with the GMC , eligible to apply for GMC Specialist Register, at time of appointment and hold a current licence to practise.
- MRCP, or equivalent
- Experience in paediatrics, neurology, or clinical genetics
Desirable
- Proven Knowledge of GPC guidelines
- Completed/ working towards degree in the speciality or related field
Personal and People Development
Essential
- Takes responsibility for own personal development plan
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Applying for this NHS job
This advert is for Clinical Research Fellow with University College London Hospitals NHS Foundation Trust in London, London, England. It is listed as a Junior Medical doctor Neurology role. The advertised salary is £54,499 per annum + London Weighting. The contract type is Fixed term: 12 months (Limited Funding). The application deadline is 05 Jul 2026.
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